For moderate to severe RA
I
HAVE RHEUMATOID ARTHRITIS.
Your results may vary. In medical studies, ENBREL was shown to be effective in about 2 out of 3 adults
w ith m oderate to severe rheum atoid arthritis (RA) who used it, and has been shown to begin working in
as few as 2 weeks, with most patients receiving benefit within 3 months. In an RA medical study, 55% of
patients had no progression of joint damage.
Please see Im portant Safety Inform ation below and M edication Guide on the back of the following page.
ENBREL is indicated for reducing signs and
symptoms, keeping joint damage from getting worse,
and improving physical function in patients with
moderate to severe rheumatoid arthritis. ENBREL
can be taken with methotrexate or used alone.
IMPORTANT SAFETY INFORMATION
What is the most important information
I should know about ENBREL?
ENBREL is a medicine that affects your immune
system. ENBREL can lower the ability of your
immune system to fight infections. Serious
infections
have
happened
in
patients taking
ENBREL. These infections include tuberculosis
(TB) and infections caused by viruses, fungi, or
bacteria that have spread throughout the body.
Some patients have died from these infections.
Your doctor should test you for TB before you
take ENBREL and monitor you closely for TB
before, during, and after ENBREL treatment, even
if you have tested negative for TB.
There have been some cases of unusual cancers
reported in children and teenage patients who
started using TNF blockers before 18 years of
age. Also, for children, teenagers, and adults
taking TNF blockers, including ENBREL, the
chances of getting lymphoma or other cancers
may increase. Patients with RA and psoriasis may
be more likely to get lymphoma.
Before starting ENBREL, tell your doctor if you:
• Have any existing medical conditions
• Are taking any medicines, including herbals
• Think you have, are being treated for, have
signs of, or are prone to infection. You should
not start taking ENBREL if you have any kind of
infection, unless your doctor says it is okay
• Have any open cuts or sores
• Have diabetes or an immune system problem
• Have TB or have been in close contact with
someone who has had TB
• Were born in, lived in, or traveled to countries
where there is more risk for getting TB. Ask
your doctor if you are not sure
• Live or have lived in certain parts of the country
(such as, the Ohio and Mississippi River valleys,
or the Southwest) where there is a greater risk
for certain kinds of fungal infections, such as
histoplasmosis. These infections may develop
or become more severe if you take ENBREL. If
you don't know if histoplasmosis or other fungal
infections are common in the areas where you
live or have lived, ask your doctor
• Have or have had hepatitis B
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